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Molecular and structural study of two enzymatic systems involved in cellular detoxification processes

Published on 24 January 2019

Leader

Dr Vincent Nivière
Directeur de Recherche CNRS
Laboratoire Chimie et Biologie des Métaux
CEA-Grenoble
17 avenue des Martyrs
38 054 Grenoble cedex 09

Phone: (33) 4 38 78 91 09
e.mail : vniviere@cea.fr


The understanding of the catalytic mechanisms of original enzyme systems in relation with their functions within the cells represents a major challenge in modern biology. As part of this problem, my current researches focus on the molecular and structural studies of two different enzyme systems involved in cellular detoxification processes:

Superoxide reductase SOR, a metalloenzyme involved in the fight against oxidative stress
MsrPQ, a new discovered system repairing oxidized methionine residues, allowing bacterial resistance to hypochlorous acid (HOCl) stress.