The understanding of the catalytic mechanisms of original enzyme systems in relation with their functions within the cells represents a major challenge in modern biology. As part of this problem, my current researches focus on the molecular and structural studies of two different enzyme systems involved in cellular detoxification processes:
• Superoxide reductase SOR, a metalloenzyme involved in the fight against oxidative stress
• MsrPQ, a new discovered system repairing oxidized methionine residues, allowing bacterial resistance to hypochlorous acid (HOCl) stress.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.