Juan Fontecilla-Camps
Institut de Biologie Structurale
Protein-bound Iron-sulfur clusters play many important roles in biology. Among them are electron transfer, gas redox catalysis, as Lewis acids and in gene expression regulation. After having been involved in the structure-function relationships of most of these activities, in the last few years several colleagues and I have concentrated our efforts on the structural biology of the latter. During my seminar I will discuss and compare the way the iron-sulfur clusters of three bacterial proteins, namely NsrR, RsrR and FNR, modulate gene expression through protein conformational changes caused by different effectors: NO, cell redox status and oxygen, respectively
Invité par Vincent Artero