I stopped my activities related to this thematic in 2021 but the former work description can be found
here.
Furthermore, we recently published several recent papers on titanium oxide Nanoparticles
[1-4] and Silver nanoparticles
[5-7], one on the demonstration of a ligand-Promoted Surface Solubilization of TiO
2 Nanoparticles by the Enterobactin Siderophore in Biological Medium, the other on TiO
2 NPs coating and photocatalytic paints properties.
Titanium dioxide nanoparticles We recently published several recent papers on titanium oxide nanoparticles
[1-4], one on the demonstration of a ligand-Promoted Surface Solubilization of TiO
2 Nanoparticles by the Enterobactin Siderophore in Biological Medium, the other on TiO
2 NPs coating and photocatalytic paints properties.
Titanium dioxide nanoparticles (TiO
2-NPs) are increasingly used in consumer products for their particular properties.
Even though TiO
2 is considered chemically stable and insoluble, studying their behavior in biological environments is of great importance to take into account figure their potential dissolution and transformation. The interaction between TiO
2-NPs with different sizes and crystallographic forms (anatase and rutile) and the strong chelating enterobactin (ent) siderophore was investigated to look at a possible dissolution. For the first time, direct evidence of anatase TiO
2-NP surface dissolution or solubilization (
i.e., the removal of Ti atoms located at the surface) in a biological medium by this siderophore was shown and the progressive formation of a hexacoordinated titanium–enterobactin (Ti–ent) complex observed. From a health and environmental point of view, the effects associated to the solubilization of the E171 TiO
2 food additive solubilization in the presence of enterobactin and the entrance of the Ti–enterobactin complex in
E. coli bacteria are were questioned. The impact of TiO
2NP and Ti on
E. coli iron homeostasis and iron containing impact would be interesting to decipher.
Safer-by-design approaches were investigated to develop specific innovative TiO
2-based photocatalytic paint, based on titanium nanoparticles’ bio-inspired coating. This strategy improved the photocatalytic activity compared to a classical paint and allowed a reduction of nano-TiO
2 release into the environment. This approach allowed the reduction of nano-titanium quantity incorporated into the paint for an equivalent photocatalytic activity compared to a classical paint. The results confirm the interest of adding TiO
2 NPs inside paints for air purification with a lower release into the environment throughout the whole life cycle of paints.
[1] Ligand-Promoted Surface Solubilization of TiO
2 Nanoparticles by the Enterobactin Siderophore in Biological Medium. J Laisney, M Chevallet, C Fauquant, C Sageot, Y Moreau,D Predoi, N Herlin-Boime, C Lebrun and I Michaud-Soret. Biomolecules, 2022, 12(10), 1516. https://doi.org/10.3390/biom12101516
[2] Towards the development of Safer by Design TiO
2-based photocatalytic paint: impacts and performances. A. Rosset, V. Bartolomei, J. Laisney, N. Shandilya, H. Voisin, J. Morin, I. Michaud-Soret, I. Capron, H. Wortham, G. Brochard, V. Bergé, M. Carrière, F. Dussert, O. Le Bihan, C. Dutouquet, A. Benayad, D. Truffier-Boutry, S.Clavaguera and S. Artous. Environ. Sci.: Nano, 2021, 8, 758-772. DOI: 10.1039/D0EN01232G.
[3] TiO
2 nanoparticles coated with bio-inspired ligands for the safer-by-design development of photocatalytic paints. Laisney, J.; Rosset, A.; Bartolomei, V.; Predoi, D.; Truffier-Boutry, D.; Artous, S.; Berge, V.; Brochard, G.; Michaud-Soret, I. Environ. Sci.:Nano, 2021, 8 (1), 297-310
[4] Towards the development of safer by design mineral TiO
2-based photocatalytic paint: influence of the TiO
2 coating on particles release. A. Rosset, I. Michaud-Soret, I. Capron, G. Brochard, V. Bergé, A. Benayad, A. Guiot, S. Clavaguera, S. Artous*. Environ. Sci.: Nano, 2024, en revision
Silver nanoparticles We recently published several recent papers. Silver nanoparticles are broadly used in consumer products and medical devices leading to human exposure and eventually accumulation in the liver. On the basic science side, we study the fate and solubilization of silver nanoparticles within hepatocytes. Silver nanoparticles efficiently dissolve into toxic Ag(I) species that are distributed in all organelles including the nucleus, where they trigger an endocrine disruptor-like mechanism
[5].
On the more applied side, we develop new Safer-by-Design concept for nanomaterials, which consists of an assembly of silver nanoparticles linked together by a bio-inspired molecule. This nanomaterial with biocidal properties releases Ag(I) ions in a slow and controlled manner, unlike the AgNPs currently in use, which undergo uncontrolled processes of transformation and product release.
[6, 7]
[5] Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles. Tardillo Suárez V., Karepina E., Chevallet M., Gallet B., Cottet-Rousselle C., Charbonnier P., Moriscot C., Michaud-Soret, I., Bal W., Fuchs A.,Tucoulou R., Jouneau PH., Veronesi G. and Deniaud A. Environ. Sci.: Nano, 2020, 7, 1373
[6] Safer-by-design biocides made of tri-thiol bridged silver nanoparticle assemblies. Marchioni, M.; Veronesi, G.; Worms, I.; Ling, W. L.; Gallon, T.; Leonard, D.; Gateau, C.; Chevallet, M.; Jouneau, P. H.; Carlini, L.; Battocchio, C.; Delangle, P.; Michaud-Soret, I., Deniaud, A. Nanoscale Horiz., 2020,5, 507-513. doi: 10.1039/c9nh00286c
[7] Thiolate Capped Silver Nanoparticles: Discerning Direct Grafting from Sulfidation at the Metal–Ligand Interface by Interrogating the Sulfur Atom. Marchioni M., Battocchio C., Joly Y., Gateau C., Nappini S., Pis I., Delangle P., Michaud-Soret I., Deniaud A., Veronesi G. Journal of Physical Chemistry C, 2020, 124 (24), pp.13467- 13478. ff10.1021/acs.jpcc.0c03388ff.