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Post-doctoral subject

Synthetic biology to approach Friedreich ataxia


Funded post-doctoral internship.
Published on 15 March 2019
Context
The Laboratory of Chemistry and Biology of Metals (LCBM) is a mixed laboratory (CEA, CNRS, Univ. Grenoble Alpes) which is part of the IRIG institute at the CEA-Grenoble. The laboratory, at the interface between chemistry and biology, focuses on the study of the structure, activity and regulation of complex biological systems using or transporting metals.

A 1-year postdoctoral fellowship is available in the "Biocatalysis" team (headed by S. Ollagnier de Choudens) of the LCBM that investigates the assembly and reactivity of iron-sulfur proteins at molecular level. The project is financed by the Agence National de la recherche (ANR).

Summary of the project
• Synthetic biology is an exciting and emerging field using engineering principles to re-design biological system with innovative and useful functionalities. The aim of this project is to re-design the essential mitochondrial ISC Fe-S biogenesis pathway to provide new therapeutic discovery and to increase our fundamental knowledge on Fe-S biogenesis. We will focus on the human disease Friedreich ataxia that is characterized by a strong deficit in the ISC pathway due to a deficiency in frataxin (FXN). We will explore different approaches to identify mutation in the ISC system that will allow it to bypass the essential role of FXN. This project will take advantage of the recently generated E. coli strain with a FXN-dependent ISC system and the well characterized FXN deficiency cell and mouse models. This project will be carried out by three internationally recognized team in the field with remarkable complementary expertise: H. Puccio (IGBMC, Illkirch) for human genetics; B. Py (LCB, Marseille) for bacterial genetics and S. Ollagnier (LCBM, Grenoble) for molecular aspects.

Miscellaneous information
• The candidate for the Biocatalysis team (CEA Grenoble) should have a strong expertise in biochemistry, a background in enzymology and an interest for structural biology. Candidates should preferably have defended their PhD in the last 2 years.
• Estimated start date: October 2019
• Duration: 1 year
• Financing: ~2000-2200 € / month
• Employer: CDD / CNRS
• Place of work: IRIG institute, CEA-Grenoble, Rhône-Alpes, France
• Applications should be sent to:
Sandrine Ollagnier :
Laboratoire Chimie et Biologie des Métaux
Équipe BioCatalyse
CEA-Grenoble
17 avenue des Martyrs
38054 Grenoble Cedex 9

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