RV1464 is a cysteine desulfurase and RV1465 a zinc-dependent protein. Zinc is required for RV1465 sulfurtransferase activity and for the SufS-SufU interaction.
Mtb SufS-SufU complex is more resistant to oxidative stress than
E. coli SufS-SufE and that the presence of zinc in SufU is likely responsible for this improved resistance, explaining why
Mtb possesses a SufSU system rather than SufSE.
