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MsrQ is a substrate of the flavin reductase Fre in E. coli


​​​​​​​​​Recently, we demonstrated that the membrane-bound MsrQ, which specifically supplies electrons to MsrP for catalyzing the reduction of Met-SO, contains not only a heme cofactor but also a flavin FMN located on the cytoplasmic side of the membrane.​
Published on 22 September 2021

​Moreover, we discovered that the cytosolic flavin reductase Fre efficiently transfers electrons from NADH to the heme cofactor through a novel mechanism involving FMN exchange between the active sites of MsrQ and Fre.






MsrPQ system to repair methionine residues oxidized by HOCl (Met-SO) 

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Concerning MsrPQ: