Mohamed​​ Atta, Olivier Hamelin, Philippe Carpentier

​​In our group, one theme of research is dedicated to pioneering the development of artificial metalloenzymes designed for the activation of small molecules such as H_₂O, N_₂, and CO_₂. By harnessing the synergy between metal catalysis and protein engineering, we aim to create novel biocatalysts with enhanced reactivity, stability and selectivity for sustainable chemical transformations. This project represents a strong collaboration between our research group and the team of Professor Marc Fontecave at Collège de France, Paris. This partnership brings together complementary expertise and resources, enabling us to tackle these challenges with a multidisciplinary approach. By combining our strengths in protein chemistry, spectroscopy, X-ray structure analysis, and catalytic activities, we are positioned at the forefront of biocatalysis innovation.

Research Focus

Protein Chemistry
     Design and engineering of metalloenzymes (Heme and Fe-S based proteins)
     Site-specific incorporation of metal cofactors
     Optimization of protein scaffolds for enhanced catalytic performance

Spectroscopy
     Advanced spectroscopic techniques to elucidate enzyme mechanisms
     In-situ monitoring of catalytic processes
     Characterization of electronic and structural properties of metalloenzymes

X-ray Structure Analysis
     High-resolution X-ray crystallography to determine enzyme structures
     Structural insights into substrate binding and activation
     Structure-guided design of improved metalloenzymes

Photocatalytic and Electrocatalytic Activities
     Development of photocatalytic systems for light-driven reactions
     Exploration of electrocatalytic pathways for efficient energy conversion
     Integration of artificial metalloenzymes in photocatalytic and electrocatalytic devices. ​
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