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PhD defense
Exposure of human cells to radiation can have a significant impact on the immune response. Irradiation of cells causes stress, leading to an inflammatory response in the tissues. Inflammation is a physiological process regulated by the activity of the NF-κB protein. This protein has early and transient activity kinetics in response to high doses of X-rays, resulting in the production of inflammatory factors in endothelial cells. The response described is only observed in endothelial cells. Irradiation with carbon ions at different energies appears to modify the inflammatory response quantitatively and qualitatively in endothelial cells. An anti-apoptotic protein called BIRC3 is also induced in irradiated endothelial cells. We are seeking to inactivate the gene encoding this protein to determine whether it protects cells against radiation-induced cell death.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.