Our project is to investigate the relationships between the formation of amyloid deposits and the abnormal apoptosis, which are features common to neurodegenerative disorders. To do so, in vivo experiments were performed on mouse model of neurodegenerative pathology.
Our team is a combination of chemists, biochemists and biologists interested in metal-catalyzed biotransformations. The research projects are located at the interface between chemistry and biology, as far as concepts but also methods are concerned. Our work aims at understanding and mimicking the molecular chemistry of complex biological reactions at both the structural and reactivity levels.
The research program of the team deals then with the design of selective bio-inspired catalysts for oxidation and reduction reactions. Our final goal is the design of enantioselective catalysts, respectful of natural resources. The aim is to develop new methodologies of chemistry for a greater control and a better understanding of chemical reactions.
The Biology of Metals team focuses on the molecular and cellular mechanisms responsible for intracellular traffic, storage and regulation of various metal ions; the group studies the homeostasis of some essential metals such as copper, iron and zinc in prokaryotic and eukaryotic cells.
We manage several computing techniques from bioinformatics to the most advanced QM/MM studie. We are able to predict protein structure and interactions using standard molecular mechanics (MM) and molecular dynamics (MD), in both all atom and coarse grained simulations.
About one third of proteins are known to harbor a metal site, which is essential for their function. The metal ion can play various roles such as structuring the protein, transferring electrons or catalyzing hydrolytic or redox reactions. Our team takes its inspiration from the metal sites of proteins and makes use of the properties of transition metal ions to design molecular catalysts for various reactions that are otherwise difficult to achieve.
The research team develops three interconnected themes, in addition to technological developments for proteomics, running as a background project. The central project deals with the responses of myeloid cells to metallic ions and nanoparticles. One project deals with the responses of the bacterium Bacillus subtilis to metallic ions and nanoparticles. The third project is centered on molecular studies in radio-induced inflammation, with a focus on the activation and function of macrophages in this process.
The SolHyCat team is engaged in several projects aiming at developing new photocathode materials for H2 evolution and their integration into a fully operative Photo-Electro-Chemical (PEC) cell. Both solid-state and fully molecular-immobilized systems are targeted.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.