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Physicochemistry of Metals in Biology team

Published on 29 March 2019



Team leader

Dr. Geneviève Blondin
CNRS research director

Laboratoire Chimie et Biologie des Métaux
CEA-Grenoble
17 avenue des Martyrs
38 054 Grenoble Cedex

Secretary
Phone: 04 38 78 21 44
Fax: 04 38 78 54 65



About one third of proteins are known to harbor a metal site, which is essential for their function. The metal ion can play various roles such as structuring the protein, transferring electrons or catalyzing hydrolytic or redox reactions.

Our team takes its inspiration from the metal sites of proteins and makes use of the properties of transition metal ions to design molecular catalysts for various reactions that are otherwise difficult to achieve. Two types of reactions are currently under investigation for synthetizing amines: (i) nitrene transfer and (ii) the conversion of alcools by tandem cascade catalysis.
Another research axis focuses on metallopeptides with two objectives: (i) to design and study models of zinc or iron sites of metalloproteins in order to understand their reactivity and (ii) to design probes for the detection of metal cations or biomolecules by luminescence or MRI. The research of the team relies on a strong expertise in various spectroscopies including electronic absorption, circular dichroism, luminescence and various magnetic spectroscopies (NMR, EPR, …). Moreover, the pmb team runs a Mössbauer platform dedicated to the study of iron-containing chemical and proteic systems.

Collaborations have been initiated with both French and international groups. The three research topics of the pmb team take benefit from external expertises, e.g. computational chemistry or cellular imaging and conversely several collaborations rely on our own expertise, for instance in Mössbauer spectroscopy.



Team members

Catalysis:
Jean-Marc Latour
CEA Researcher
Amélie Kochem
CNRS
Researcher
PatrickDubourdeaux
CEA Engineer
Guillaume Coin
PhD student
Jordan Donat
PhD student
Ikram Yagoub
PhD student

Metallopeptides:

Olivier Sénèque
CNRS
Researcher
Guillaume Frémy
PhD student
Patrick Malikidogo
Post-doc
Ji-Hyung Choi
PhD student
Thibault Charnay
PhD student

Mössbauer:

Geneviève Blondin
CNRS
Researcher
Martin Clémancey
UGA
Engineer
Ricardo Garcia-Serres
UGA lecturer
Jean-Marc Latour
CEA
Researcher


Keywords

Metallopeptides, Chemical models, Catalysis, Mössbauer, Spectroscopy