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Despite the phytosanitary (molecular target of herbicides) and pharmaceutical interests (HPPD inhibitors are used as therapeutic agents and are undergoing clinical trials in the treatment of Parkinson's disease), the reaction mechanism of 4-hydroxyphenylpyruvate dioxygenase (HPPD) has not yet been fully elucidated. We determined the role of catalytic residues that may interact with the substrate and with the reaction intermediates of HPPD.
Thesis presented on November 28, 2017 by Rolf David. PhD thesis available as a pdf file.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.