Chemistry and Biology of Metals laboratory UMR 5249 CNRS-CEA-UGA - Welcome

The scientific project of the Chemistry and Biology of Metals laboratory (CBM) conducts research at the interface of chemistry and biology. The work focuses on the study of the structure, activity and regulation of complex biological systems that transport and use metal ions, and on the exploitation of this knowledge to develop bio-inspired systems with similar structures and/or functions.

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Bioenergy & Environment Team

The “BioEnergy & Environment” team focus its interests on the bio-activation of small molecules by metalloenzymes and anaerobic micro-organisms.
Biocatalysis team

The BioCatalysis team (BioCat) focuses on the maturation and reactivity of iron metalloproteins, with applications in the health and energy sectors.
Bioinspired Chemistry and Environment team

The research program of the team deals then with the design of selective bio-inspired catalysts for oxidation and reduction reactions. Our final goal is the design of enantioselective catalysts, respectful of natural resources. The aim is to develop new methodologies of chemistry for a greater control and a better understanding of chemical reactions.
Computational chemistry, Modelling, and X-rays

Our group brings together experts in computational and quantum chemistry methods (DFT, WFT, QM/MM), classical simulation (MD, Docking), and synchrotron X-ray techniques (XAS, XRF).
Metals & Organs Team

The team is interested in the study of metal homeostasis in mammals in both physiological and pathological contexts as well as in the case of environmental exposure to metals such as metal nanoparticles.
Physicochemistry of Metals in Biology team

About one third of proteins are known to harbor a metal site, which is essential for their function. The metal ion can play various roles such as structuring the protein, transferring electrons or catalyzing hydrolytic or redox reactions. Our team takes its inspiration from the metal sites of proteins and makes use of the properties of transition metal ions to design molecular catalysts for various reactions that are otherwise difficult to achieve.
Proteomics for Microbiology, Immunology and Toxicology team

The research team develops three interconnected themes, in addition to technological developments for proteomics, running as a background project. The central project deals with the responses of myeloid cells to metallic ions and nanoparticles. One project deals with the responses of the bacterium Bacillus subtilis to metallic ions and nanoparticles. The third project is centered on molecular studies in radio-induced inflammation, with a focus on the activation and function of macrophages in this process.
SolHyCat team

The SolHyCat team is engaged in several projects aiming at developing new photocathode materials for H 2 evolution and their integration into a fully operative Photo-Electro-Chemical (PEC) cell. Both solid-state and fully molecular-immobilized systems are targeted.

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Internships, Theses, Post-docs Available
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Platforms & Instrumental facilities

Alternative and Atomic Energies Agency

CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.

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