The “BioEnergy & Environment” team focus its interests on the bio-activation of small molecules by metalloenzymes and anaerobic micro-organisms.
Our team is a combination of chemists, biochemists and biologists interested in metal-catalyzed biotransformations. The research projects are located at the interface between chemistry and biology, as far as concepts but also methods are concerned. Our work aims at understanding and mimicking the molecular chemistry of complex biological reactions at both the structural and reactivity levels.
The research program of the team deals then with the design of selective bio-inspired catalysts for oxidation and reduction reactions. Our final goal is the design of enantioselective catalysts, respectful of natural resources. The aim is to develop new methodologies of chemistry for a greater control and a better understanding of chemical reactions.
Our group brings together experts in computational and quantum chemistry methods (DFT, WFT, QM/MM), classical simulation (MD, Docking), and synchrotron X-ray techniques (XAS, XRF).
The team is interested in the study of metal homeostasis in mammals in both physiological and pathological contexts as well as in the case of environmental exposure to metals such as metal nanoparticles.
About one third of proteins are known to harbor a metal site, which is essential for their function. The metal ion can play various roles such as structuring the protein, transferring electrons or catalyzing hydrolytic or redox reactions. Our team takes its inspiration from the metal sites of proteins and makes use of the properties of transition metal ions to design molecular catalysts for various reactions that are otherwise difficult to achieve.
The research team develops three interconnected themes, in addition to technological developments for proteomics, running as a background project. The central project deals with the responses of myeloid cells to metallic ions and nanoparticles. One project deals with the responses of the bacterium Bacillus subtilis to metallic ions and nanoparticles. The third project is centered on molecular studies in radio-induced inflammation, with a focus on the activation and function of macrophages in this process.
The SolHyCat team is engaged in several projects aiming at developing new photocathode materials for H 2 evolution and their integration into a fully operative Photo-Electro-Chemical (PEC) cell. Both solid-state and fully molecular-immobilized systems are targeted.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.