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Sulphur in Biology

Only four proteins are described as being able to achieve radical direct insertion of a sulfur atom in a CH bond of biomolecules. The poorly understood mechanism behind such an insertion reflect at most one turnover in vitro. These systems are called "sacrificial" because the sulfur of the FeS centers of these proteins is the one which is found in the substrate. Thanks to this new publication, we propose a mechanism allowind these enzyme systems to achieve more in vitro turnover.​​

Published on 26 April 2013

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Reactions catalysed by MiaB (A) and RimO (B).

Three-dimensional structure of the RimO enzyme

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