We have identified in
Escherichia coli, in collaboration with a bacterial microbiology team of Marseille (UPR-CNRS 9043), a third system enabling the maturation of iron-sulfur centers. This new system would play a specific role in the maturation of a protein involved in the biosynthesis of nicotinamide adenine dinucleotide, a cofactor involved in cellular respiration (glycolysis). This discovery could challenge the assumption of the central role played by the protein scaffold in the biosynthesis of iron-sulfur proteins and in the related molecular mechanisms.